The study conducted in collaboration with the Oulu University Hospital tested the possibility of using propofol-induced slow-wave activity as an early predictor of neurologic outcome after cardiac arrest. As the editors of the journal point out, no reliable methods currently exist for assessing brain function in the early stages of recovery from hypoxic, ischemic, or traumatic insults that might inform neurologic prognosis and therapy.
In the study of comatose cardiac arrest survivors, propofol-induced slow-wave activity was present in a greater proportion of patients with good neurologic outcome than in those with poor outcome. The promising finding of the study is expected to lead to the development of a pharmacologic test for the prognostication of brain injury.
Cerenion Oy has received support from the European Regional Development Fund of the European Union.
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